After the mission of the tail beast, Kakashi start to have bad feeling. Tsunade sent Kakashi and Naruto, Sakura, and Sai to investigate on missing ninja. Kakashi realize that there is something wrong. Kakashi report to Tsunade and tell her that those missing ninja are protected.
Tsunade start to thing of something but Kakashi think of something happen in the past. Tsunade see Kakashi having a problem and ask Kakashi “what is wrong.” Kakashi tell Tsunade it was nothing.
News was spread out to all nation. Hiruko is back. Tsunade went outside to see Hiruko. Tsunade cannot believe that Hiruko is back. Hiruko spread that konoha will attack all nation. Tsunade was worried and tell everyone that we have to defend konoha. Tsunade went to the Fire nation to ask for there help but they want evidence of that konoha was not the enemy.
At night, Kakashi meet Tsunade at the office. Tsunade see Kakashi is worried. Tsunade ask Kakashi “what is wrong?” Kakashi tell Tsunade about Hiruko at his past. Tsunade started to remember the mission in her past of investigate Hiruko. Tsunade realize that Hiruko went to meet Kakashi. Kakashi tell Tsunade that Hiruko “put a brain control on me.”
Tsunade went to shock that Hiruko plan was getting Kakashi. Tsunade tell Kakashi that “I will protect you.”
Kakashi tell Tsunade you can’t, and also tell about the plan of Hiruko. Tsunade look at the days and see it only couple day left of Kakashi been not control. Kakashi tell Tsunade that he got a plan. Tsunade say to Kakashi that people will go to hate me. Kakashi tells Tsunade that your Will of Fire is to let the people that you care for, to go. Afterward, Tsunade spent time with Kakashi and Tsunade think this is last time to see Kakashi.
After Kakashi left, Tsunade is wait to see Gaara. Tsunade start to feel something bad is going to happen. When Jiraiya show up, Jiraiya tell Tsunade that Naruto save Kakashi. Tsunade simile and knows that Naruto will save Kakashi.
At the end Tsunade return to konoha and see Kakashi and others come back.